Tag Archives: Acupuncture

Shaftesbury Clinic Star of Conditions

Acupuncture Research Resources

Blog, , , , ,

Over 4 million acupuncture treatments are carried out annually in the UK. Musculoskeletal pain is the most common presenting symptom, although people seek acupuncture for a wide variety of conditions and issues.

Acupuncture has a very high satisfaction rate amongst users, according to research.

References: British Acupuncture Council Research Digest, evidence based factsheet about acupuncture research including specific research, trials and mechanisms of action for acupuncture in various conditions.

Helen
Posted on: May-15-2021 10:35 am
0 comment
Tags: , , , , ,
Shaftesbury Clinic Star of Conditions

Pelvic Pain – Condition Resources

Blog, , ,

Important to know: Chronic health conditions should be addressed under direct medical supervision of your GP or consultant, and acupuncture would be an adjunct or complement to usual care – we advise that you let you doctor know when you use this approach.

About the research: It is worth noting that in research, randomised controlled studies (RCT) are the most reliable in terms of quality of evidence, with a systematic review or meta analysis of numerous studies being the best way of seeing the overall picture of the state of the evidence. Below we have a selection of the available research, which does include some larger RCTs, and reviews of the literature alongside smaller studies. The n= figure tells you how many people were participants in the study.

Chronic Pain in General

“Acupuncture is effective for the treatment of chronic musculoskeletal, headache, and osteoarthritis pain. Treatment effects of acupuncture persist over time and cannot be explained solely in terms of placebo effects. Referral for a course of acupuncture treatment is a reasonable option for a patient with chronic pain”. (Vickers et al, 2018: large chronic pain review of high quality RCTs updating a previous meta-analysis; 39 trials, n=20827; conditions addressed chronic headache, back/neck pain and osteoarthritis)

Another recent overview (Yin et al, 2017) confirms that there is increasing evidence for acupuncture  as an effective, safe, and cost-effective intervention in chronic low back, neck, shoulder, and knee pain, as well as headaches.

The NHS body in charge of which treatments should be used in particular conditions recommends acupuncture for chronic pain:  The NICE Scenario Management guidelines (2021) for chronic pain state: “consider a course of acupuncture or dry needling, within a traditional Chinese or Western acupuncture system”

Overall, a large systematic review has found acupuncture a cost effective intervention for several painful conditions (Ambrósio et al, 2012).

Pelvic Pain and Conditions

Prostatitis related bladder symptoms and pain: Acupuncture has been found to be beneficial in reducing the symptoms of prostatitis, including urinary symptoms (Franco et al, 2019). 

Chronic prostatitis/chronic pelvic pain syndrome: A systematic review and meta-analysis found that acupuncture showed promise from the RCTs that they reviewed (Chang et al, 2017).

Mechanisms of action:

Acupuncture studies have shown it can: provide pain relief by stimulating nerves in body tissues and leading to endorphin release (natural painkilling substances), as well as downregulating the brain and nervous system’s reaction to stress and pain (Zhao 2008; Zijlstra et al, 2003; Pomeranz, 1987).

Acupuncture stimulates the body to create its own natural painkilling substances, such as Beta Endorphins (β-Endorphin). In studies acupuncture has been shown to stimulate the production of natural painkillers called opioid-like peptides (OLPs), including β-Endorphin: For example, this was shown in an RCT in 90 patients with a range of painful disorders (Petti et al, 1998). The same study showed acupuncture also and enhanced the activity of immune cells (lymphocytes, natural killer cells and monocytes) that help fight infections and diseases (Petti et al, 1998).

Acupuncture can activate mast cells at acupoints, which release histamine, serotonin, adenosine, and other mediators that modulate nerve transmission and inflammation (Li et al, 2022)

Zijlstra et al (2003) reviewed the effects and mechanisms of acupuncture in treating various inflammatory diseases and conditions. They proposed the mechanisms of action:

  • Acupuncture may release neuropeptides from nerve endings that have vasodilative and anti-inflammatory effects through CGRP.
  • Acupuncture may also interact with substance P, which is involved in pain transmission and inflammation.
  • Acupuncture may contribute to analgesia by stimulating the release of β-endorphin, which binds to opioid receptors and inhibits pain signals.
  • Acupuncture may influence the balance between cell-specific pro-inflammatory and anti-inflammatory cytokines such as TNF-α and IL-10.

Acupuncture has been shown in animal models to promote the release of factors that involved in the reduction of inflammation (vascular and immunomodulatory factors – (Kim et al, 2008; Kavoussi and Ross, 2007 [review article]; Zijlstra et al, 2003), and also to affect levels of serotonin (in an animal model), and other peptides in the brain and nervous system and modulate blood flow in the brain and elsewhere in the body, in humans (Zhong and Li, 2007; Shi et al, 2010).

Resources:

Evidence Based Acupuncture Factsheet on Pain

References:

General Chronic Pain References:

Vickers, A.J., Vertosick, E.A., Lewith, G., MacPherson, H., Foster, N.E., Sherman, K.J., Irnich, D., Witt, C.M., Linde, K. and Acupuncture Trialists’ Collaboration, 2018. Acupuncture for chronic pain: update of an individual patient data meta-analysis. The Journal of Pain, 19(5), pp.455-474.

Birch, S., Lee, M.S., Alraek, T. and Kim, T.H., 2018. Overview of treatment guidelines and clinical practical guidelines that recommend the use of acupuncture: a bibliometric analysis. The Journal of Alternative and Complementary Medicine, 24(8), pp.752-769.

NICE 2021 Chronic pain: Scenario: Management Last revised in April 2021

Yin, C., Buchheit, T.E. and Park, J.J., 2017. Acupuncture for chronic pain: an update and critical overview. Current opinion in anaesthesiology, 30(5), pp.583-592.

Mechanism Of Action in Pain References:

Kavoussi B, Ross BE. The neuroimmune basis of anti-inflammatory acupuncture. Integr Cancer Ther. 2007 Sep;6(3):251-7.

Kim HW, Uh DK, Yoon SY et al. Low-frequency electroacupuncture suppresses carrageenan-induced paw inflammation in mice via sympathetic post-ganglionic neurons, while high-frequency EA suppression is mediated by the sympathoadrenal medullary axis. Brain Res Bull. 2008 Mar 28;75(5):698-705.

Li, Y., Yu, Y., Liu, Y. and Yao, W., 2022. Mast cells and acupuncture analgesia. Cells, 11(5), p.860.

Petti, F.., Bangrazi, A., Liguori, A., Reale, G. and Ippoliti, F., 1998. Effects of acupuncture on immune response related to opioid-like peptides. Journal of Traditional Chinese Medicine 18(1), pp.55-63.

Pomeranz B. Scientific basis of acupuncture. In: Stux G, Pomeranz B, eds. Acupuncture Textbook and Atlas. Heidelberg: Springer-Verlag; 1987:1-18.

Shi H, Li JH, Ji CF, Shang HY, Qiu EC et al.[Effect of electroacupuncture on cortical spreading depression and plasma CGRP and substance P contents in migraine rats]. Zhen Ci Yan Jiu. 2010 Feb;35(1):17-21.

Zhao ZQ. Neural mechanism underlying acupuncture analgesia. Prog Neurobiol. 2008 Aug;85(4):355-75.

Zhong G.-W. Li W. Effects of acupuncture on 5-hydroxytryptamine1F and inducible nitricoxide synthase gene expression in the brain of migraine rats. Journal of Clinical Rehabilitative Tissue Engineering Research. 2007;11(29)(pp 5761-5764)

Zijlstra FJ, van den Berg-de Lange I, Huygen FJ, Klein J. Anti-inflammatory actions of acupuncture. Mediators Inflamm. 2003 Apr;12(2):59-69.

Prostatitis References:

Chang, S.C., Hsu, C.H., Hsu, C.K., Yang, S.S.D. and Chang, S.J., 2017. The efficacy of acupuncture in managing patients with chronic prostatitis/chronic pelvic pain syndrome: a systemic review and meta‐analysis. Neurourology and urodynamics, 36(2), pp.474-481.

Franco, J.V., Turk, T., Jung, J.H., Xiao, Y.T., Iakhno, S., Garrote, V. and Vietto, V., 2019. Non‐pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome: a Cochrane systematic review. BJU international, 124(2), pp.197-208.

Helen
Posted on: May-1-2021 13:58 pm
0 comment
Tags: , , ,
Shaftesbury Clinic Star of Conditions

Sciatica – Condition Resources

Blog, , , , , , , , ,

Important to know: Chronic health conditions should be addressed under direct medical supervision of your GP or consultant, and acupuncture would be an adjunct or complement to usual care – we advise that you let you doctor know when you use this approach.

Sciatica

Sciatica is also known by its medical name lumbar radiculopathy, and is where nerves become impinged in the lower back, causing referred pain and neurological (nerve-related) symptoms into the areas that nerve supplies, usually buttock and lower limb.

Evidence suggests acupuncture may provide pain relief in sciatica; RCTs such as Wang (2009; n=139) comparing acupuncture and TENS and finding in favour of acupuncture; another finding for acupuncture’s effectiveness along with an increase in pain threshold in the true acupuncture group (Chen et al, 2009; n=90).

Other studies have looked at how the above may come about, for example Inoue et al (2008), in a clinical trial where patients had improvement in pain and nerve symptoms from lower back impingement, and put forward the theory that as seen in animal studies the blood flow in the region of the sciatic nerve was modulated by acupuncture, as well as the well known mechanisms of action of acupuncture in pain relief and inflammation reduction.

A network meta-analysis comparing 21 different therapies for sciatica (Lewis et al, 2015), finding acupuncture the second-best therapy in terms of addressing pain intensity and in terms of overall effect and having a statistically significant effect, leading them to suggest it should be considered as a treatment option.

Back pain

There is a strong correlation between back pain and sciatica, for which reason the following may be of interest.

Many parts of the NHS either offer or recommend acupuncture for back pain, with over 100 clinical practice guidelines worldwide giving positive recommendations for acupuncture for back pain (Birch et al, 2018).  The Scottish Intercollegiate Guidelines Network recommends acupuncture for back pain.

Back pain was included in large chronic pain review of RCTs updating a previous meta-analysis (Vickers et al, 2018; 39 trials, n=20827) acupuncture showed a significant clinical superiority over usual care and a smaller advantage over sham.  The researchers found that treatment effects persisted over time and couldn’t be explained solely in terms of placebo effects, meaning that acupuncture treatment was a reasonable option for some types of chronic pain, including back pain.

The American College of Physicians’ clinical practise guidelines nonpharmacologic treatment options for low back pain reviewed new evidence and found acupuncture useful for pain relief and to some extent function, although they had reservations about the strength of the evidence, meaning long term studies are needed (Chou et al, 2016, 2017).

The Clinical Practise Guidelines for managing low back pain, a systematic review on 13 sets of guidelines by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration looked at non-invasive techniques including acupuncture – acupuncture was one of the top recommended (non-invasive) interventions in the guidelines, where 10 sessions over 12 weeks was the recommended intervention for low back pain, and commented that high-quality guidelines support this whilst underlining that different techniques have different levels of effectiveness (Wong et al, 2017).

Another recent overview (Yin et al, 2017) confirms that there is increasing evidence for acupuncture  as an effective, safe, and cost-effective intervention in chronic low back pain.

Mechanisms of Action

Acupuncture stimulates the body to create its own natural painkilling substances, such as Beta Endorphins (β-Endorphin). In studies acupuncture has been shown to stimulate the production of natural painkillers called opioid-like peptides (OLPs), including β-Endorphin: For example, this was shown in an RCT in 90 patients with a range of painful disorders (Petti et al, 1998). The same study showed acupuncture also and enhanced the activity of immune cells (lymphocytes, natural killer cells and monocytes) that help fight infections and diseases (Petti et al, 1998).

Acupuncture can activate mast cells at acupoints, which release histamine, serotonin, adenosine, and other mediators that modulate nerve transmission and inflammation (Li et al, 2022)

About the research: It is worth noting that in research, randomised controlled studies (RCT) are the most reliable in terms of quality of evidence, with a systematic review or meta analysis of numerous studies being the best way of seeing the overall picture of the state of the evidence. Below we have a selection of the available research, which does include some larger RCTs, and reviews of the literature alongside smaller studies. The n= figure tells you how many people were participants in the study.

Resources:

British Acupuncture Council evidence based factsheet about Sciatica including specific research, trials and mechanisms of action for acupuncture in this condition.

References:

Sciatica References:

Chen, M.R., Ping, W., Cheng, G., Xiang, G.U.O., Wei, G.W. and Cheng, X.H., 2009. The warming acupuncture for treatment of sciatica in 30 cases. Journal of Traditional Chinese Medicine, 29(1), pp.50-53.

Inoue, M., Kitakoji, H., Yano, T., Ishizaki, N., Itoi, M. and Katsumi, Y., 2008. Acupuncture treatment for low back pain and lower limb symptoms—the relation between acupuncture or electroacupuncture stimulation and sciatic nerve blood flow. Evidence-Based Complementary and Alternative Medicine, 5(2), pp.133-143.

Lewis, R.A., Williams, N.H., Sutton, A.J., Burton, K., Din, N.U., Matar, H.E., Hendry, M., Phillips, C.J., Nafees, S., Fitzsimmons, D. and Rickard, I., 2015. Comparative clinical effectiveness of management strategies for sciatica: systematic review and network meta-analyses. The Spine Journal, 15(6), pp.1461-1477.

Li, Y., Yu, Y., Liu, Y. and Yao, W., 2022. Mast cells and acupuncture analgesia. Cells, 11(5), p.860.

Wang ZX. [Clinical observation on electroacupuncture at acupoints for treatment of senile radical sciatica]. Zhongguo Zhenjiu 2009; 29(2): 126-8.

Back Pain References:

Vickers, A.J., Vertosick, E.A., Lewith, G., MacPherson, H., Foster, N.E., Sherman, K.J., Irnich, D., Witt, C.M., Linde, K. and Acupuncture Trialists’ Collaboration, 2018. Acupuncture for chronic pain: update of an individual patient data meta-analysis. The Journal of Pain, 19(5), pp.455-474.

Birch, S., Lee, M.S., Alraek, T. and Kim, T.H., 2018. Overview of treatment guidelines and clinical practical guidelines that recommend the use of acupuncture: a bibliometric analysis. The Journal of Alternative and Complementary Medicine, 24(8), pp.752-769.

Chou, R., Deyo, R., Friedly, J., Skelly, A., Hashimoto, R., Weimer, M., Fu, R., Dana, T., Kraegel, P., Griffin, J. and Grusing, S., 2017. Nonpharmacologic therapies for low back pain: a systematic review for an American College of Physicians Clinical Practice Guideline. Annals of internal medicine, 166(7), pp.493-505.

Chou, R., Deyo, R., Friedly, J., Skelly, A., Hashimoto, R., Weimer, M., Fu, R., Dana, T., Kraegel, P., Griffin, J. and Grusing, S., 2016. Noninvasive treatments for low back pain.

Wong, J.J., Côté, P., Sutton, D.A., Randhawa, K., Yu, H., Varatharajan, S., Goldgrub, R., Nordin, M., Gross, D.P., Shearer, H.M. and Carroll, L.J., 2017. Clinical practice guidelines for the noninvasive management of low back pain: A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. European journal of pain, 21(2), pp.201-216.

Lewis, R.A., Williams, N.H., Sutton, A.J., Burton, K., Din, N.U., Matar, H.E., Hendry, M., Phillips, C.J., Nafees, S., Fitzsimmons, D. and Rickard, I., 2015. Comparative clinical effectiveness of management strategies for sciatica: systematic review and network meta-analyses. The Spine Journal, 15(6),

Petti, F.., Bangrazi, A., Liguori, A., Reale, G. and Ippoliti, F., 1998. Effects of acupuncture on immune response related to opioid-like peptides. Journal of Traditional Chinese Medicine 18(1), pp.55-63.

Yin, C., Buchheit, T.E. and Park, J.J., 2017. Acupuncture for chronic pain: an update and critical overview. Current opinion in anaesthesiology, 30(5), pp.583-592.pp.1461-1477.

Helen
Posted on: Mar-16-2021 14:17 pm
0 comment
Tags: , , , , , , , , ,
Shaftesbury Clinic Star of Conditions

Gynaecology – Condition Resources

Blog, , ,

Important to know: Chronic health conditions should be addressed under direct medical supervision of your GP or consultant, and acupuncture would be an adjunct or complement to usual care – we advise that you let you doctor know when you use this approach.

Acupuncture is a popular choice for women for a number of issues relating to the menstrual cycle, fertility, pregnancy, post-partum, PMS and the menopause. A large number of research-based factsheets have been produced by the British Acupuncture Council, outlining research finding for many gynaecological conditions (see “resources” at the base of this page for links).

A scholarly search of the available research studies on “acupuncture” + “gynaecology” reveals over 8,400 papers from journals, and narrowing this to + “RCT” leads to over 1,250 hits, of which 40% have been carried out since 2017. From this we can deduce that acupuncture is widely used and scientifically researched in gynaecological conditions, and that the pace at which the research is being carried is increasing – leading us to understand this is an area worthy of appraisal.

Below (under Resources) is a list of specific conditions for which the British Acupuncture Council (BAcC) has produced evidence-based factsheets regarding many aspects of women’s reproductive health.

The BAcC has also produced a paper on gynaecology and acupuncture, which in addition looks at the use and evidence of effectiveness of acupuncture in dysmenorrhoea, dysfunctional uterine bleeding and chronic pelvic inflammatory disease, where the BAcC concluded that there is a growing body of evidence to support the value of acupuncture in addressing these conditions.

Pregnancy: Acupuncture is safe in pregnancy, but do ensure you tell your midwife (and consultant if you are under one) that you’re using it, and also tell your acupuncturist if you are pregnant or trying for a baby, as there are certain points which must be avoided in pregnancy.

About the research:

The means and quality of how research is carried out varies considerably from country to country, and in terms of how an intervention is compared to another intervention (or a control).  It is very important to note that “sham” acupuncture where needles are placed other than in acupuncture points it not an inert process and that comparing sham and “true acupuncture” may therefore not give a clear picture alone, but and form a part of a research body where acupuncture versus no treatment, conventional treatment or a different approach also form part of the evidence base.

A large number of resources are available in the References section below, as well as in the BAcC’s factsheets.  When reading the research it is important to know that systematic reviews or meta analyses of a large number of high-quality research studies are the very best way to be able to say to what extent a given treatment can address a condition, symptom, or set of symptoms.  The next best level of evidence is the randomised controlled study (RCT) which uses a systematic technique to compare two or more groups of patients receiving different treatments (or a treatment against a “control” of no treatment).  As mentioned above, the control group is of particular interest in how acupuncture trials are carried out as it is hard to blind a patient to whether they are having a needle inserted or not, and even more challenging to blind the researcher to this.  In the case of animal studies (as discussed below) it is easier to make more objective measures and avoid placebo effect. In studies the n= figure tells you how many people were participants in the study.

Research studies have been done on various aspects of acupuncture and the female reproductive system, to examine measurable effects occurring in the body following acupuncture, these look at levels of certain hormones and neurotransmitters (chemical messengers) in the blood, scans of the brain in action (fMRI) and other objective measures that can be compared on a before- and after- basis.

Research into mechanisms of action indicates that acupuncture can modulate activity in many of the body’s regulatory systems, including the nervous system; endocrine system and influence the levels of different hormones and neurotransmitters (chemical signals) in the body, blood stream and brain (Stener-Victorin, 2006; Stener-Victorin and Wu, 2010; Gerhard et al, 1992). Experimental studies have also shown acupuncture to improves blood flow to the uterus and ovaries (Stener-Victorin et al, 1996 (n=10 women’s uterine artery blood flow impedance was measured after electro-acupuncture treatment). 

Another type of research commonly carried out is in animal models, primarily rats, where measurements can be made as to the effects of acupuncture.  Here, any placebo effect and subjectivity on outcomes is overcome by the fact that objective measures of levels of hormones in the blood, etc can be made.  The hormones and neurotransmitters that have been shown to be thus influenced in physiological studies include:

  • Gonadotrophin releasing hormone (GnRH) increased in the hypothalamus in a rat model using specific acupuncture points and channels,  (Wang et al, 2010; Zhu et al, 2019 – points used SP6 and ST36); electroacupuncture normalised circulating gonadotrophin levels in a rat model (Maliqueo et al, 2015)
  • LH (luteinizing hormone) and progesterone blood levels have been found to be significantly raised by true acupuncture treatment at points ST36 and SP6 in a rat model, (He et al, 2009), the same study also found vascular endothelial growth factor levels in the ovaries to be raised in the rats which received true acupuncture (versus sham acupuncture at nearby non-points
  • Blood Cortisol and Prolactin (PRL) levels were normalised in acupuncture patients a study of 67 women undergoing IVF during ovarian stimulation (Magarelli et al, 2009, Magarelli et al, 2006), prolactin levels influenced by acupuncture in laboratory rat models (Sheng and Xie, 1989; Xiong et al, 2015; Liu et al, 2007) 
  • Testosterone and Estradiol – in a rat model the use of CV4, CV3, SP6 and Zigong points downregulated testosterone and estradiol (in females) and improved the development of their reproductive organs (Zhang et al, 2009)

See our Fertility and Pregnancy page for full details on the studies and mechanisms of the above.

Resources:

The British Acupuncture Council has several relevant evidence based factsheets about Women’s Health, including specific research, trials and mechanisms of action for acupuncture in these conditions.

BAcC Childbirth and acupuncture factsheet

BAcC Dysmenorrhoea (painful periods) and acupuncture factsheet

BACC Diabetes (includes Gestational Diabetes)

BAcC Endometriosis and acupuncture factsheet

BAcC Female Fertility and acupuncture factsheet

BAcC Infertility and ART factsheet

BAcC Fertility and IVF briefing paper

BAcC Male Infertility Factsheet

BAcC Menopausal Symptoms and acupuncture factsheet

BAcC Obstetrics (pregnancy and childbirth) and acupuncture factsheet

BAcC PCOS (Polycystic Ovarian Syndrome) and acupuncture factsheet

BAcC Premenstrual Syndrome and acupuncture factsheet

BAcC Puerperium (postnatal / postpartum) acupuncture factsheet

The British Acupuncture Council also has a review paper on Gynaecology and acupuncture: The evidence for effectiveness

Our own page on Fertility, Pregnancy and Acupuncture

Our own blog on Acupuncture and the Menopause

References:

Gerhard I, Postneek F. Auricular acupuncture in the treatment of female infertility. GynecolEndocrinol. 1992 Sep;6(3):171-81. 

He, D.J. Huang G.Y. Zhang M.M. [Effects of acupuncture on the luteal function of rats with dysfunctional embryo implantation] [Chinese]. Zhongguozhenjiu. 2009; 29(11):910-913

Magarelli, P.C.; M. Cohen, D.K. Cridennda Proposed mechanism of action of acupuncture on IVF outcomes Fertility and Sterility, Vol. 86, Issue 3, S174-175 Published in issue: September 2006 

Magarelli, Paul C.; Diane K. Cridennda, Mel Cohen, Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization embryo transfer treatment, Fertility and Sterility, Volume 92, Issue 6, December 2009, Pages 1870-1879

Maliqueo, M., Benrick, A., Alvi, A., Johansson, J., Sun, M., Labrie, F., Ohlsson, C. and Stener-Victorin, E., 2015. Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or β-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome. Molecular and Cellular Endocrinology, 412, pp.159-169.

Sheng, P.L. and Xie, Q.W., 1989. Relationship between effect of acupuncture on prolactin secretion and central catecholamine and R-aminobutyric acid. Zhen ci yan jiu= Acupuncture research, 14(4), pp.446-451.

Stener-Victorin, E. and Humaidan, P., 2006. Use of acupuncture in female infertility and a summary of recent acupuncture studies related to embryo transfer. Acupuncture in Medicine, 24(4), pp.157-163.

Stener-Victorin E, Waldenstraum U, Andersson SA, Wikland M. Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture. Hum Reprod. 1996 Jun;11(6):1314-7

Stener-Victorin, E. and Wu, X., 2010. Effects and mechanisms of acupuncture in the reproductive system. Autonomic Neuroscience, 157(1-2), pp.46-51.

Wang, S.J., Bing, Z.H.U., Ren, X.X. and Tan, L.H., 2010. Experimental study on acupuncture activating the gonadotropin-releasing hormone neurons in hypothalamus. Journal of Traditional Chinese Medicine, 30(1), pp.30-39.

Xiong, F., Gui, J., Yang, W., Li, J. and Huang, G.Y., 2015. Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction. Chinese journal of integrative medicine, 21(1), pp.58-66.

Zhang WY, Huang GY, Liu J. [Influences of acupuncture on infertility of rats with polycystic ovarian syndrome] [in Chinese] ZhongguoZhong Xi Yi Jie He ZaZhi. 2009 Nov;29(11):997-1000.

Zhu, H., Nan, S., Suo, C., Zhang, Q., Hu, M., Chen, R., Wan, J., Li, M., Chen, J. and Ding, M., 2019. Electro-acupuncture affects the activity of the hypothalamic-pituitary-ovary axis in female rats. Frontiers in physiology, 10, p.466.

Helen
Posted on: Mar-16-2021 9:29 am
0 comment
Tags: , , ,
Coronavirus Update

Coronavirus Update

Blog, Research, Shaftesbury Clinic, , , , ,

We’re open for practise with COVID-19 secure gudelines

We are now open for all treatments, in line with the British Acupuncture Council COVID-19 Secure Guidelines

Risk Assessment

We have undertaken a risk assessment on the premises and practise, and have made the necessary changes to mitigate and minimise all identified risks, as per BAcC and HSE and government guidelines.  The important aspects you need to be aware of, are as below.

The acupuncturist carries out a risk assessment regarding each patient, to ensure that attending in person is appropriate, as for example if you are shielding or in a high risk group, this still will not be possible for the time being.

Telephone triage/screening before you attend

Please also note that your practitioner will contact you on the day of treatment to check that you are not symptomatic of Covid-19, and other related checks to ensure it’s safe for you to attend.

The acupuncturist will do as much of the verbal consultation on the telephone prior to the appointment to minimise the amount of time exposure in the treatment room.  They will discuss your symptoms and circumstances with you.

All this is in line with the guidelines for safe practise of our regulatory body, the British Acupuncture Council (BAcC), and national government guidance.

Consent

You will need to complete a specific consent form in order to undertake  treatment at this time, your acupuncturist will advise on the specifics of this.

Changes to the rooms and equipment

In accordance with government guidelines and those of the BAcC British Acupuncture Council we have made changes to the rooms in which we practise, and the way in which we work in order to do so safely in this unprecedented time.  You will notice less chairs, no waiting area (a chair is provided for emergencies) and you are encouraged not to use the toilet onsite unless in an emergency.  You’ll notice more posters and safety equipment, as well as the use of PPE for you and the practitioner in the treatment room.

You’ll be asked to wash your hands or use alcohol gel on entering the premises, and you’ll see more in the way of cleaning equipment occurring.  You’ll be reminded to keep 2 metres away from anyone from outside your household, including the practitioner; with the exception of the treatment itself where PPE is used due to unavoidable proximity.  Your treatment may be shorter than usual, as we will have completed the talking element of the treatment by phone, prior to the treatment. We intend to minimise the time we spend in the 2-metre zone, to less than 15mins,- minimising both our risk.  We will leave larger gaps between patients so that cleaning can take place between patients.

Useful to know on the day

If you are attending for urgent care the following is a useful reminder (although not exhaustive and you will have discussed with your acupuncturist):

  • Check your symptoms and those of your household – your acupuncturist will make a pre-appointment phone call to screen for this
  • Use the toilet before you leave home as we need to keep the numbers of users to a minimum as cleaning is needed between users (you can of course use it in an emergency but must let your practitioner know so that they can arrange cleaning)
  • Be on time, and not early as there is no waiting facility. We recommend travelling by car, walking or cycling.  If you must use public transport, there are specific government guidelines on this here including mandatory masks on public transport, for example
  • Do not wait outside the front door, or use the buzzers, instead text your practitioner from your car, or text from the car park or pavement outside whilst keeping socially distant from anyone else who is waiting
  • Bring the minimum of items with you, so no shopping or large bags, and please bring the items your practitioner requests, e.g. face mask, towel, bottle of water

Further information

Specific government advice for this sector, should you wish to read it first-hand is here: Close contact working

Bear in mind that guidance changes, sometimes daily as a result of the R number and the government’s 5 tests, and therefore and we will keep this up to date as this happens, but the primary source of what can and cannot be safely done remains government guidelines here: https://www.gov.uk/coronavirus – which over-arches all of the above.

Information correct per government websites at 14/07/2020

Helen
Posted on: Jun-7-2020 12:50 pm
0 comment
Tags: , , , , ,
Shaftesbury Clinic Star of Conditions

Raynaud’s Phenomenon – Condition Resources

Blog, Conditions, Research, Shaftesbury Clinic, , , ,

Under Construction

The British Acupuncture Council (BAcC) has an evidence based factsheet on Raynaud’s Phenomenon and acupuncture.

Important to know: Chronic health conditions should be addressed under direct medical supervision of your GP or consultant, and acupuncture would be an adjunct or complement to usual care – we advise that you let you doctor know when you use this approach.

About the research: It is worth noting that in research, randomised controlled studies (RCT) are the most reliable in terms of quality of evidence, with a systematic review or meta analysis of numerous studies being the best way of seeing the overall picture of the state of the evidence. Below we have a selection of the available research, which does include some larger RCTs, and reviews of the literature alongside smaller studies. The n= figure tells you how many people were participants in the study.

Resources:

British Acupuncture Council (BAcC) Raynaud’s Phenomenon factsheet

BAcC Research Digest

Helen
Posted on: Jul-17-2019 14:13 pm
0 comment
Tags: , , , ,

Can acupuncture help me reduce my medications?

Blog, Conditions, latest post, , , , , , , , , , , , , , ,

I am often asked permutations of this question, and my answer is that acupuncturists are not doctors, and deciding to change or reduce medication must always be done under a doctor’s supervision. It is important to have these conversations with your medical team, and it’s crucial if you are considering making changes to medications, that your GP and any consultants whose care you are under, are up to date on what you are doing.

Pharmacists can also be a very helpful resource, and in particular if you are using over the counter medications, they can advise you of contraindications and interactions they may have with your prescribed medications.

In terms of acupuncture and working with patients, some of the reasons people are looking at introducing complementary medicines and coming to us, is for example to help them reduce the number of painkillers they are taking, or see if we can do something to help their side-effects.  This can be very helpful as long as we have a team approach, realistic expectations and discussions, and the patient is also working with their GP or consultant.

The research evidence for acupuncture is growing, and we find that medical professionals are more and more aware of what we do, in some cases recommending acupuncture for particular conditions, so be sure to tell you GP if you are thinking of acupuncture, and keep them up to date on how you are getting along.

Helen
Posted on: Jan-19-2018 15:42 pm
0 comment
Tags: , , , , , , , , , , , , , , ,
Shaftesbury Clinic Star of Conditions

Viral disease – Condition Resources

Blog, ,

Page under construction

Important to know: Chronic health conditions should be addressed under direct medical supervision of your GP or consultant, and acupuncture would be an adjunct or complement to usual care – we advise that you let you doctor know when you use this approach.

About the research: It is worth noting that in research, randomised controlled studies (RCT) are the most reliable in terms of quality of evidence, with a systematic review or meta analysis of numerous studies being the best way of seeing the overall picture of the state of the evidence. Below we have a selection of the available research, which does include some larger RCTs, and reviews of the literature alongside smaller studies. The n= figure tells you how many people were participants in the study.

References:

Helen
Posted on: Jul-16-2017 14:29 pm
0 comment
Tags: , ,
Shaftesbury Clinic Star of Conditions

Rheumatoid Arthritis – Condition Resources

Blog, ,

Important to know: Chronic health conditions should be addressed under direct medical supervision of your GP or consultant, and acupuncture would be an adjunct or complement to usual care – we advise that you let you doctor know when you use this approach.

Rheumatoid Arthritis is a chronic inflammatory disorder, primarily affecting the joints in the body. It can have a pattern of relapses and remissions, and pain and inflammation are some of the primary symptoms that patients are looking to address.

About the research: It is worth noting that in research, randomised controlled studies (RCT) are the most reliable in terms of quality of evidence, with a systematic review or meta analysis of numerous studies being the best way of seeing the overall picture of the state of the evidence. Below we have a selection of the available research, which does include some larger RCTs, and reviews of the literature alongside smaller studies. The n= figure tells you how many people were participants in the study.

Studies

Feng et al (2023) conducted a systematic review and meta-analysis of 17 RCTs comparing electroacupuncture (EA) plus medication with other treatments, such as medication alone, or sham acupuncture for Rheumatoid Arthritis. Measures of clinical efficacy, pain scores (visual analogue scale, VAS), disease activity score in 28 joints (DAS28), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and adverse events were compared. The results showed that EA plus medication had a superior effect than medication alone or other treatments, in improving clinical efficacy, VAS, DAS28, CRP, and ESR. The authors concluded that EA plus medication is an effective and safe treatment for RA, but more high-quality studies are needed to confirm its long-term benefits and mechanisms.

Electroacupuncture has been shown to alleviate symptomatic knee pain in rheumatoid arthritis (Casimiro et al 2005; Cochrane review).

A systematic review and meta-analysis of 21 animal studies (Yu et al, 2023) investigated acupuncture’s effect on pain and swelling of arthritis animal models. Acupuncture was found to increase tolerance to pain stimuli and reduce swelling in arthritis animals, the researchers suggested possible mechanisms of action as being via nervous and immune system regulation.

Mechanisms of Action:

A review article (Kavoussi & Ross, 2007) suggests that the anti-inflammatory actions that have been demonstrated to be brought about by acupuncture may be mediated via activation of the vagus nerve, alongside deactivation of inflammatory macrophages and other proinflammatory cytokines.  The researchers concluded that “The use of acupuncture as an adjunct therapy to conventional medical treatment for a number of chronic inflammatory and autoimmune diseases seems plausible and should be validated by confirming its cholinergicity”. 

Other studies (Zijlstra et al, 2003) have revealed that acupuncture some of the pain modulating and anti-inflammatory effects seen in acupuncture trials may be due to the fact that it has been shown to stimulate certain substances in the body which act as vasodilators, neurotransmitters and painkillers (beta-endorphins, CGRP and substance P) and further stimulate cytokines and nitric oxide, all of which play roles in inflammatory states. 

Zijlstra et al (2003) reviewed the effects and mechanisms of acupuncture in treating various inflammatory diseases and conditions. They proposed the mechanisms of action:

  • Acupuncture may release neuropeptides from nerve endings that have vasodilative and anti-inflammatory effects through CGRP.
  • Acupuncture may also interact with substance P, which is involved in pain transmission and inflammation.
  • Acupuncture may contribute to analgesia by stimulating the release of β-endorphin, which binds to opioid receptors and inhibits pain signals.
  • Acupuncture may influence the balance between cell-specific pro-inflammatory and anti-inflammatory cytokines such as TNF-α and IL-10.

CSR and ERP are blood tests related to the functioning of the immune system, that can measure and monitor inflammation in the body.  They are relevant to conditions such as Rheumatoid Arthritis, and other immune and inflammatory conditions.  Per a review by Feng at al, (2023) electroacupuncture (EA) plus medication had a significant effect in lowering both ESR and CRP levels in patients with RA compared with medication alone.  These results suggest that EA may have an anti-inflammatory effect and improve the immune status of patients with RA.

Inflammatory and immune markers:  Wang et al (2008) reviewed the evidence from 8 RCTs for acupuncture as a treatment for rheumatoid arthritis (RA) that compared acupuncture with placebo or active drug interventions. Five studies observed a reduction in the inflammatory/immune marker of ESR and three noted a reduction in CRP level after acupuncture treatment.

Acupuncture can activate mast cells at acupoints, which release histamine, serotonin, adenosine, and other mediators that modulate nerve transmission and inflammation (Li et al, 2022)

Wang et al (2023) reviewed evidence from animal and human studies regarding the immunomodulatory mechanism of acupuncture, regarding its effects on different components of the immune system, such as mast cells, macrophages, neutrophils, natural killer cells, astrocytes, microglia, CD4+ and CD8+ T cells, and cytokines.  They detailed the neuroanatomical mechanisms of acupuncture in immunomodulation, such as the vagal-adrenal pathway, the cholinergic anti-inflammatory pathway, the spinal sympathetic pathway, the brain-gut axis, and the hypothalamus-pituitary-adrenal axis.  They concluded that studies to support the role of acupuncture in regulating inflammation, infection, allergy, pain, and tissue repair.

Acupuncture has also been shown in human research trials, to downregulate the areas of the brain associated with sensitivity to pain and stress, which may also contribute to its contribution to addressing pain issues (Hui et al, 2010).

Animal Models

Specifically acupuncture in an animal model has also demonstrated improvement in inflamed synovium which is characteristic of Rheumatoid Arthritis (He et al, 2010).

An animal model study (Sun et al, 2023; n=36) investigated the effects of electroacupuncture (EA) on rheumatoid arthritis (RA) in rats, plus its underlying mechanisms. They showed that acupuncture helped RA outcome measures of paw oedema, pain responses, serum cytokines, synovial inflammation, in collagen-induced arthritis (CIA) rats.  They were able to show that RA worked by blocking a pathway in the synovium called TLR2/4, that activates immune response and inflammation.  The researchers therefore suggested the anti-inflammatory and analgesic effects of EA were related to the inhibition of TLR2/4 signalling on synovial fibroblasts and macrophages.

Inflammation modulation: Liu et al (2014) investigated the anti-inflammatory effect of electroacupuncture (EA) in a rat tissue chamber model of inflammation. The study found that EA inhibited the p65 protein from moving to the cell nucleus to activate inflammatory genes.  EA also increased the expression of IκBα, which binds to NF-κB and preventing it from entering the nucleus to activate inflammatory genes. These interfere with the IκB/NF-κB pathway that regulates inflammation, indicating one of the mechanisms of acupuncture in modulating immune / inflammatory response.

Electroacupuncture (EA) has been shown in a rat model (Li et al, 2008) to have anti-inflammatory benefits by modulating the hypothalamic-pituitary-adrenal (HPA) axis, (HPA axis regulates the stress response and immune function).  Specifically, Li et al outlined that EA sets off a cascade in the brain (via corticotropin-releasing hormone, and adrenocorticotropic hormone) to produce cortisol, which reduces inflammation and oedema.

References:

Casimiro, L., Barnsley, L., Brosseau, L., Milne, S., Welch, V., Tugwell, P. and Wells, G.A., 2005. Acupuncture and electroacupuncture for the treatment of rheumatoid arthritis. Cochrane Database of Systematic Reviews, (4).

Feng, Y., Zhang, R., Zhao, Z., He, Y., Pang, X., Wang, D. and Sun, Z., 2023. Efficacy and safety of electroacupuncture combined with medication for rheumatoid arthritis: A systematic review and meta-analysis. Heliyon.

Kavoussi B, Ross BE. The neuroimmune basis of anti-inflammatory acupuncture. Integr Cancer Ther 2007;  6:  251-7.

He, T.F., Zhang, S.H., Li, L.B., Yang, W.J., Zhu, J. and Chen, Y.F., 2010. Effects of acupuncture on the number and degranulation ratio of mast cells and expression of tryptase in synovium of rats with adjuvant arthritis. Zhong xi yi jie he xue bao= Journal of Chinese integrative medicine, 8(7), pp.670-677.

Hui, K.K., Marina, O., Liu, J., Rosen, B.R. and Kwong, K.K., 2010. Acupuncture, the limbic system, and the anticorrelated networks of the brain. Autonomic Neuroscience, 157(1-2), pp.81-90.

Li, A., Lao, L., Wang, Y., Xin, J., Ren, K., Berman, B.M., Tan, M. and Zhang, R., 2008. Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation. BMC Complementary and Alternative Medicine, 8(1), pp.1-8.

Li, Y., Yu, Y., Liu, Y. and Yao, W., 2022. Mast cells and acupuncture analgesia. Cells, 11(5), p.860.

Liu, F., Fang, J., Shao, X., Liang, Y., Wu, Y. and Jin, Y., 2014. Electroacupuncture exerts an anti-inflammatory effect in a rat tissue chamber model of inflammation via suppression of NF-κB activation. Acupuncture in Medicine, 32(4), pp.340-345.

MacPherson H, Blackwell R, 1994. Rheumatoid Arthritis and Chinese Medicine: a Review. European J of Oriental Medicine 1(3) 17-29

Sun, S.Y., Yan, Q.Q., Qiao, L.N., Shi, Y.N., Tan, L.H. and Yang, Y.S., 2023. Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine, 2023.

Wang, C., De Pablo, P., Chen, X., Schmid, C. and McAlindon, T., 2008. Acupuncture for pain relief in patients with rheumatoid arthritis: a systematic review. Arthritis Care & Research: Official Journal of the American College of Rheumatology, 59(9), pp.1249-1256.

Wang, M., Liu, W., Ge, J. and Liu, S., 2023. The immunomodulatory mechanisms for acupuncture practice. Frontiers in Immunology, 14.

Yu, W.L. and Kim, S.N., 2023. The effect of acupuncture on pain and swelling of arthritis animal models: A systematic review and meta-analysis. Frontiers in Genetics, 14.

Zijlstra, F.J., van den Berg-de Lange, I., Huygen, F.J. and Klein, J., 2003. Anti-inflammatory actions of acupuncture. Mediators of inflammation, 12(2), pp.59-69.

Helen
Posted on: Oct-16-2016 14:15 pm
0 comment
Tags: , ,
Shaftesbury Clinic Star of Conditions

Urinary Incontinence – Condition Resources

Blog, , , , , ,

Important to know: Chronic health conditions should be addressed under direct medical supervision of your GP or consultant, and acupuncture would be an adjunct or complement to usual care – we advise that you let you doctor know when you use this approach.

The British Acupuncture Council has looked at some recent trials in its research digest (see link below), including an RCT (n= 504 over 12 hospitals – multicentre trial; Lu et al, 2017), which found a positive trend in less urine leakage for the acupuncture group after 6 weeks for women with stress urinary incontinence.

A systematic review and meta-analysis of 10 RCTs (n=794 in total) found acupuncture may decrease micturation (urination) episodes, night time urination and improve patients’ quality of life, although further research was warranted (Zhao et al, 2018)

For more information on the urinary system and acupuncture, see our dedicated page on Bladder Issues

About the research: It is worth noting that in research, randomised controlled studies (RCT) are the most reliable in terms of quality of evidence, with a systematic review or meta analysis of numerous studies being the best way of seeing the overall picture of the state of the evidence. Below we have a selection of the available research, which does include some larger RCTs, and reviews of the literature alongside smaller studies. The n= figure tells you how many people were participants in the study.

References:

Liu, Z., Liu, Y., Xu, H., He, L., Chen, Y., Fu, L., Li, N., Lu, Y., Su, T., Sun, J. and Wang, J., 2017. Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical trial. Jama, 317(24), pp.2493-2501.

Zhao, Y., Zhou, J., Mo, Q., Wang, Y., Yu, J. and Liu, Z., 2018. Acupuncture for adults with overactive bladder: a systematic review and meta-analysis of randomized controlled trials. Medicine, 97(8).

Resources:

British Acupuncture Council evidence based factsheet about Urinary Incontinence including specific research, trials and mechanisms of action for acupuncture in this condition.

British Acupuncture Council Research digest – Urinary Incontinence (just over halfway down the document)

Helen
Posted on: Aug-12-2016 14:27 pm
0 comment
Tags: , , , , , ,